| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide |
| Cas No. | |
| Form | Off-white to yellow crystals |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Storage |
Sirtinol is a selective, cell-permeable inhibitor of sirtuin deacetylases (IC50: 38 µM for SIRT2, 68 µM for Sir2p, 131 µM for SIRT1), with no effect on HDAC1. Sirtuins are key regulators of aging, stress response, and neurodegeneration.
Sirtinol’s specificity enables precise investigation of sirtuin-mediated pathways in neuronal survival, synaptic plasticity, and neuroinflammation. Its relevance in Alzheimer’s and Parkinson’s research is growing, as sirtuin-targeted therapies gain traction. Sirtinol is widely used in neuroscience to explore epigenetic mechanisms underlying cognitive decline and neuronal resilience.
Classification: Caution. Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Sirtinol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-360)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Mai A., et al (2005) J.Med.Chem. 48: 7789.
3. Kahyo T., et al (2008) J.Pharmacol.Sci. 108: 364.
4. Jung-Hynes B., et al (2009) J.Biol.Chem. 284: 3823.
