| Field | Specification |
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| Mfr No | |
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| Host | |
| Immunogen | E.coli-derived human SLC15A5 recombinant protein (Position: D10-L579) was used as the immunogen for the SLC15A5 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SLC15A5 Antibody / Solute carrier family 15 member 5 is a anti-SLC15A5 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: SLC15A5
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, ELISA
Biological background
Functionally, SLC15A5 antibody identifies a 579-amino-acid transmembrane transporter characterized by multiple hydrophobic segments that form a peptide permeation pathway. While the physiological substrates of SLC15A5 remain under investigation, its sequence homology with other SLC15 family members (such as SLC15A1/PEPT1 and SLC15A2/PEPT2) suggests it operates as a proton-dependent symporter. SLC15A5 likely participates in regulating peptide and amino acid availability in neuronal and glial cells, supporting neurotransmitter synthesis and signaling balance.
The SLC15A5 gene is located on chromosome 12q21.31 and is expressed primarily in the central nervous system, with highest levels observed in cerebellum and hippocampus. Expression is tightly regulated during neural development and may respond to metabolic or synaptic activity changes. In addition to its neuronal role, SLC15A5 expression has been reported in skeletal muscle and testis, indicating potential tissue-specific transport functions.
Pathologically, disruption of SLC15A5 expression has been linked to neurological and psychiatric conditions. Variants in the SLC15A5 locus have been associated with susceptibility to major depressive disorder and cognitive dysfunction. Abnormal transporter activity may affect brain peptide signaling and synaptic communication. Research using SLC15A5 antibody supports studies in membrane transport, neurobiology, and metabolic regulation.
SLC15A5 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect peptide transport proteins.
Structurally, Solute carrier family 15 member 5 contains 12 predicted transmembrane helices forming a transporter channel and cytoplasmic domains involved in proton coupling and regulation. Conserved motifs typical of the SLC15 family mediate substrate binding and conformational shifts during the transport cycle. This antibody enables investigation of SLC15A5's role in neuronal physiology, peptide metabolism, and cellular transport processes.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
