| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human FATP2/SLC27A2 recombinant protein (Position: F27-D608) was used as the immunogen for the SLC27A2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SLC27A2 Antibody / FATP2 is a anti-SLC27A2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm (ER), cell membrane.
Key elements and design rationale
- Target: SLC27A2
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, IHC, FACS, ELISA
Biological background
Structurally, FATP2 is an integral membrane protein of approximately 70 kilodaltons containing an AMP-binding domain and a transmembrane domain that anchors it to the endoplasmic reticulum and peroxisomal membranes. By simultaneously transporting and esterifying fatty acids, FATP2 ensures efficient channeling of lipids into metabolic and anabolic pathways. It exhibits substrate preference for long-chain and polyunsaturated fatty acids, regulating lipid composition in liver and kidney tissues where it is abundantly expressed.
The SLC27A2 antibody is widely used in lipid metabolism, endocrinology, and mitochondrial research to study fatty acid transport, oxidation, and storage. Western blot analysis detects a 70 kilodalton band corresponding to FATP2, while immunofluorescence reveals peroxisomal and ER-associated staining. This antibody is an essential reagent for investigating lipid homeostasis and the mechanisms linking fatty acid uptake to metabolic regulation.
FATP2 expression is upregulated in metabolic and inflammatory conditions, including nonalcoholic fatty liver disease and insulin resistance. Its deficiency disrupts fatty acid activation and leads to altered lipid accumulation, oxidative stress, and impaired peroxisomal function. In cancer cells, FATP2 supports rapid proliferation by promoting fatty acid uptake and lipid synthesis, making it a potential therapeutic target in metabolic oncology. The SLC27A2 antibody provides a reliable tool for detecting FATP2 expression, studying fatty acid channeling, and evaluating its role in disease-associated metabolic remodeling.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
