| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human OATP14/SLCO1C1 recombinant protein (Position: M1-L712) was used as the immunogen for the SLCO1C1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SLCO1C1 Antibody / Solute carrier organic anion transporter family member 1C1 / OATP14 is a anti-SLCO1C1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Rat.
Key elements and design rationale
- Target: SLCO1C1
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, ELISA
Biological background
Functionally, SLCO1C1 antibody targets a transmembrane glycoprotein belonging to the solute carrier (SLC) superfamily, subfamily SLCO, which facilitates sodium-independent transport of amphipathic organic compounds including hormones, bile acids, and drugs. In the brain, SLCO1C1 is essential for delivering thyroid hormones necessary for neuronal differentiation and metabolism. Loss of SLCO1C1 function or genetic variants reduce T4 influx into the brain, contributing to thyroid hormone deficiency and impaired neurological development. Beyond the brain, SLCO1C1 transcripts have been detected in the testis, placenta, and endothelial cells, suggesting broader roles in hormone clearance and intercellular signaling.
Researchers use SLCO1C1 antibody in western blotting, immunofluorescence, and immunohistochemistry to assess expression at the blood-brain barrier and study its regulation under disease or drug-induced conditions. SLCO1C1 expression is regulated by nuclear receptors such as PXR, LXR, and HNF4alpha, integrating endocrine and metabolic cues. Polymorphisms in SLCO1C1 affect pharmacokinetics of thyroid hormone analogs and certain drugs, making it a pharmacogenomic biomarker for personalized medicine approaches. The protein contains 12 predicted transmembrane domains typical of OATP transporters, with glycosylation sites important for proper folding and localization.
The SLCO1C1 gene is located on chromosome 12p12.1 and encodes a protein of about 643 amino acids. It shares structural similarity with other OATP family members such as SLCO1A2, SLCO1B1, and SLCO1B3, but exhibits unique tissue distribution and substrate specificity. Functional studies reveal that SLCO1C1 contributes significantly to the transport of T4 and rT3 across endothelial cells, maintaining thyroid hormone gradients crucial for neuronal activity. Dysfunction in SLCO1C1 expression has been implicated in neurodevelopmental delay, cognitive impairment, and altered drug disposition in the CNS.
By enabling precise detection of this transporter, the SLCO1C1 antibody is a critical reagent for understanding thyroid hormone transport, blood-brain barrier permeability, and transporter-mediated drug delivery.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
