| Field | Specification |
|---|---|
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| Accession Number | |
| Alternative Names | Slo1, BKAlpha, maxi-K+ channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel, Subfamily M subunit alpha-1, KCa1.1, K(VCA)alpha, BK channel, BKCA alpha, Maxi K channel, Slo-alpha, Slowpoke homolog, Kcnma1, Kcnma, Maxi Potassium channel alpha, KCMA1, Slo, BKCa, mSlo, MaxiK, mSlo1, 5730414M22Rik, BK, BKCA channel, K VCA, BKCA alpha subunit, BKTM, Drosophila slowpoke like, SAKCA |
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| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Fusion protein, AA #690-1196 (cytoplasmic C-terminus) of mouse Slo1. Epitope mapped to within AA #690-715 (PKLMRHDPLLIPGNDQIDNMDSNVKK). |
| Isotype | |
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| Reactivity | |
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Slo1, also known as the BK (Big Potassium) channel or BKα, is a voltage- and calcium-activated potassium channel highly expressed in neurons and smooth muscle. It plays a critical role in regulating membrane excitability by facilitating the repolarization phase of action potentials and modulating neurotransmitter release.
Slo1 channel activity is finely tuned by intracellular Ca²⁺ levels and membrane potential, and is further regulated by auxiliary KCNMB subunits. This dynamic regulation enables Slo1 to influence synaptic transmission, motor coordination, and responses to ethanol. Notably, Slo1 dysfunction has been implicated in a range of neurological and neuromuscular disorders, including epilepsy, ataxia, hypertension, and muscular dystrophy.
Recent studies suggest that Slo1 may also contribute to neurodegenerative disease mechanisms by altering neuronal firing patterns and calcium homeostasis. Its interaction with dystrophin-related pathways further underscores its relevance in neuromuscular integrity.
Given its broad physiological roles and disease associations, Slo1 is emerging as a promising target for therapeutic intervention and biomarker development in neurodegenerative research.
1 µg/ml was sufficient for detection of Slo1 on Rat Brain Membrane lysate.
Cite this product varies by variant:
- SMC-625D — Size: 100 ug: Slo1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625D, RRID: AB_3716781)
- SMC-625D-A390 — Size: 100 ug: Slo1 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625D-A390, RRID: AB_3716782)
- SMC-625D-A488 — Size: 100 ug: Slo1 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625D-A488, RRID: AB_3716783)
- SMC-625D-A594 — Size: 100 ug: Slo1 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625D-A594, RRID: AB_3716784)
- SMC-625D-APC — Size: 100 ug: Slo1 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625D-APC, RRID: AB_3716785)
- SMC-625D-BI — Size: 100 ug: Slo1 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625D-BI, RRID: AB_3716786)
- SMC-625D-FITC — Size: 100 ug: Slo1 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625D-FITC, RRID: AB_3716787)
- SMC-625D-HRP — Size: 100 ug: Slo1 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625D-HRP, RRID: AB_3716788)
- SMC-625D-PCP — Size: 100 ug: Slo1 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625D-PCP, RRID: AB_3716789)
- SMC-625D-RPE — Size: 100 ug: Slo1 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625D-RPE, RRID: AB_3716790)
- SMC-625S — Size: 12 ug: Slo1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-625S, RRID: AB_3716781)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Latorre, R., & Brauchi, S. (2006). Large conductance Ca2+-activated K+ (BK) channel: Activation by Ca2+ and voltage. Biological Research, 39(3), 385-401. DOI: 10.4067/s0716-97602006000300003
3. Petkov G. V. (2014). Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology. American journal of physiology. Regulatory, integrative and comparative physiology, 307(6), R571–R584. DOI: 10.1152/ajpregu.00142.2014
4. Pathak, D., Guan, D., & Foehring, R. C. (2016). Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex. Journal of neurophysiology, 115(5), 2317–2329. DOI: 10.1152/jn.01028.2015
5. Kim, H., Pierce-Shimomura, J. T., Oh, H. J., Johnson, B. E., Goodman, M. B., & McIntire, S. L. (2009). The dystrophin complex controls bk channel localization and muscle activity in Caenorhabditis elegans. PLoS genetics, 5(12), e1000780. DOI: 10.1371/journal.pgen.1000781
