| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human SNTB1 recombinant protein (Position: Q83-E452) was used as the immunogen for the SNTB1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SNTB1 Antibody / Beta-1-Syntrophin is a anti-SNTB1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.
Key elements and design rationale
- Target: SNTB1
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, FACS, ELISA
Biological background
Structurally, SNTB1 contains PDZ, PH, and SU domains that mediate interactions with ion channels, kinases, and membrane receptors. It associates with the dystrophin complex through its PH domain and serves as a scaffold for signaling proteins such as neuronal nitric oxide synthase (nNOS) and voltage-gated sodium channels. By organizing these proteins at the plasma membrane, SNTB1 maintains muscle membrane stability and signal transduction efficiency.
The SNTB1 antibody is used in muscle biology, neuroscience, and membrane signaling research to study the dystrophin-associated complex and its role in muscular and neurological disorders. Western blot analysis identifies a 60 kilodalton band corresponding to SNTB1, while immunofluorescence reveals sarcolemmal and cytoplasmic staining in muscle fibers and neurons. This antibody provides a critical tool for exploring membrane-associated scaffolding and signaling mechanisms.
Mutations or altered expression of syntrophin family members, including SNTB1, contribute to muscular dystrophy, channelopathies, and synaptic dysfunction. SNTB1 also participates in signaling pathways regulating calcium homeostasis and cytoskeletal remodeling. The SNTB1 antibody supports research into these pathways and their implications in neuromuscular and cardiovascular diseases.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
