| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human SOCS7 was used as the immunogen for the SOCS7 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SOCS7 Antibody / Suppressor of cytokine signaling 7 is a anti-SOCS7 Rabbit antibody Recombinant Rabbit Monoclonal clone 30S97 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human.
Key elements and design rationale
- Target: SOCS7
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 30S97, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB, IHC
Biological background
Suppressor of cytokine signaling 7 contains a central SH2 domain and a C terminal SOCS box, which targets signaling complexes for ubiquitination and proteasomal degradation. Research using SOCS7 antibody has shown that it regulates not only STAT pathways but also insulin receptor and growth factor receptor signaling. This broadens its role beyond immune regulation into metabolism and growth control. Because it functions as a scaffold that recruits ubiquitin ligases, SOCS7 coordinates protein turnover of key signaling mediators.
In addition to its signaling roles, SOCS7 has nuclear functions. Studies with SOCS7 antibody have demonstrated that the protein translocates to the nucleus in response to DNA damage and stress, where it interacts with signaling and structural proteins to regulate cell cycle checkpoints. This nuclear activity links SOCS7 to genome stability and cellular stress responses, making it more than a classic negative regulator of cytokines.
Dysregulation of SOCS7 contributes to disease. Reduced expression can lead to prolonged signaling through pathways such as STAT3, promoting inflammation and tumorigenesis. Elevated expression may impair insulin signaling and contribute to metabolic imbalance. Research using SOCS7 antibody has explored its roles in autoimmune disease, cancer, and diabetes. By influencing multiple pathways, SOCS7 serves as a critical checkpoint in cellular signaling.
SOCS7 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting demonstrates protein abundance and post-translational modifications, immunohistochemistry highlights expression patterns in tissues such as spleen and pancreas, and immunofluorescence reveals subcellular distribution, including nuclear translocation. These applications make SOCS7 antibody an indispensable tool in signaling research.
By providing validated SOCS7 antibody reagents,
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
