| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human Serine racemase was used as the immunogen for the SRR antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SRR Antibody / Serine racemase is a anti-SRR Rabbit antibody Recombinant Rabbit Monoclonal clone 30S73 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.
Key elements and design rationale
- Target: SRR
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 30S73, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
Serine racemase is expressed primarily in astrocytes and neurons, where it controls production of D-serine in the central nervous system. Research using SRR antibody has shown that D-serine binds to the glycine site of NMDA receptors, regulating receptor activation. This makes SRR activity essential for synaptic plasticity, long-term potentiation, and cognitive function. Loss of D-serine production due to impaired SRR activity results in deficits in NMDA receptor signaling.
Dysregulation of Serine racemase is linked to neurological and psychiatric disorders. Studies with SRR antibody have revealed that reduced activity contributes to schizophrenia by decreasing D-serine availability and NMDA receptor function. Conversely, excessive D-serine production may promote excitotoxicity and neurodegeneration in conditions such as amyotrophic lateral sclerosis and Alzheimer's disease. These findings position SRR as both a biomarker and a potential therapeutic target.
Beyond the brain, Serine racemase contributes to metabolism and signaling in peripheral tissues. Research using SRR antibody has suggested roles in kidney function and immune regulation. Because D-serine influences both neural and systemic physiology, SRR is an enzyme with broad biological significance.
SRR antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects full-length and truncated forms, immunohistochemistry highlights expression in brain regions, and immunofluorescence demonstrates astrocytic and neuronal localization. These applications make SRR antibody versatile in neuroscience and physiology research.
By supplying validated SRR antibody reagents,
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
