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| Immunogen | A synthesized peptide derived from human MST4 was used as the immunogen for the STK26 antibody. |
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Overview
STK26 Antibody / MST4 / MASK is a anti-STK26 Rabbit antibody Recombinant Rabbit Monoclonal clone 29S79 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, Golgi.
Key elements and design rationale
- Target: STK26
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 29S79, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB, IHC
Biological background
STK26 antibody is commonly applied in studies of cancer, epithelial polarity, and kinase signaling. In epithelial cells, STK26 regulates apical basal polarity and tissue organization. In cancer, STK26 expression has been associated with tumor progression, migration, and invasion. By detecting STK26 expression, researchers can examine how dysregulation of this kinase influences malignancy and whether it serves as a useful biomarker.
The antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence. In western blot assays, STK26 antibody detects protein bands corresponding to the expected size, confirming expression across different samples. Immunohistochemistry highlights tissue localization of the kinase, while immunofluorescence provides single cell resolution of its cytoplasmic and membrane associated distribution. These applications make STK26 antibody a versatile tool for exploring kinase activity in diverse biological contexts.
Research has shown that STK26 interacts with adaptor proteins such as MASK and kinases like MST4, forming scaffolding complexes that integrate signaling networks. These complexes influence cell polarity, cytoskeletal organization, and transcription factor regulation. STK26 is also implicated in Hippo signaling, a pathway that governs tissue size and cellular proliferation by balancing growth and apoptosis. By using STK26 antibody, scientists can evaluate how this kinase contributes to developmental biology and disease progression.
In oncology, altered STK26 expression has been reported in certain cancers, where its activity may support invasion and metastasis. Experimental models suggest that modulation of STK26 influences tumor cell migration, making it a potential therapeutic target. Beyond cancer, STK26 plays roles in tissue morphogenesis, neuronal polarity, and immune regulation. Antibodies against STK26 therefore support a broad range of research into cellular organization and signaling.
STK26 antibody provided by
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
