| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human STOX2 recombinant protein (Position: D57-K659) was used as the immunogen for the STOX2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
STOX2 Antibody / Storkhead box protein 2 is a anti-STOX2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.
Key elements and design rationale
- Target: STOX2
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, ELISA
Biological background
STOX2 regulates gene networks involved in cell differentiation, extracellular matrix formation, and immune modulation. As a nuclear transcription factor, it binds promoter and enhancer regions to modulate expression of developmental and hormonal response genes. STOX2 expression increases during embryogenesis and trophoblast development, indicating a function in maternal-fetal interface establishment. In adult tissues, it remains expressed in epithelial and endothelial cells, maintaining homeostasis and tissue-specific gene expression.
Structurally, STOX2 contains a winged-helix DNA-binding domain typical of forkhead-like transcription factors, along with transactivation domains in its C-terminus that recruit transcriptional coactivators. It belongs to the storkhead box protein family, which includes STOX1�a transcription factor associated with preeclampsia�highlighting shared regulatory mechanisms in placental and vascular development. STOX2 may co-localize with transcriptional regulators such as SMADs in TGF-beta signaling, influencing epithelial differentiation and growth factor response.
Functionally, STOX2 contributes to placental morphogenesis and vascular remodeling. Its regulatory role in epithelial-mesenchymal transitions (EMT) and matrix deposition suggests involvement in tissue remodeling and wound repair. STOX2 may also modulate immune tolerance mechanisms at the maternal-fetal interface, ensuring proper placental development. In the nervous system, developmental expression studies show STOX2 activity during neuronal lineage specification, indicating broader roles beyond placentation.
Dysregulation of STOX2 expression has been associated with pregnancy-related disorders such as preeclampsia and intrauterine growth restriction. Aberrant promoter methylation or altered transcriptional regulation can disrupt placental gene networks. In cancer, reduced STOX2 levels have been linked to loss of epithelial integrity, while overexpression may contribute to tumor invasion through EMT activation. Pathway associations include TGF-beta signaling, Wnt signaling, and gene regulatory pathways governing developmental morphogenesis.
STOX2 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
