| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human FAM40B/STRIP2 recombinant protein (Position: H173-Q507) was used as the immunogen for the STRIP2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
STRIP2 Antibody / Striatin-interacting protein 2 is a anti-STRIP2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: STRIP2
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, IHC, FACS, ELISA
Biological background
STRIP2 is encoded by the STRIP2 gene located on human chromosome 7q34. The protein is approximately 92 kilodaltons and shares structural features with STRIP1, including coiled-coil regions that mediate interactions with striatins, kinases, and phosphatases. Through the STRIPAK complex, STRIP2 influences actin dynamics, cell polarity, and cell-cell junction formation.
The STRIP2 antibody identifies a 90-100 kilodalton protein by western blot. STRIP2 functions as a scaffold that couples kinases such as MST1/2 and MAP4Ks to PP2A, thereby controlling phosphorylation-dependent signaling cascades. This coordination regulates tissue growth, planar cell polarity, and morphogenesis.
Loss or mutation of STRIP2 disrupts cytoskeletal organization and leads to abnormal cell migration and tissue formation. In the nervous system, STRIP2 is important for axon outgrowth and synapse development. Studies have linked STRIP2 mutations to congenital myopathies and developmental disorders. In cancer, dysregulated STRIP2 expression has been observed in breast, lung, and prostate tumors, where it may promote invasive behavior.
STRIP2 serves as a crucial adaptor that integrates mechanical and chemical signaling at the cell cortex. Its interactions with the Hippo pathway components connect STRIPAK signaling to growth regulation and organ size control.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
