| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human SULT1C2 recombinant protein (Position: M1-Q251) was used as the immunogen for the SULT1C2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SULT1C2 Antibody / Sulfotransferase 1C2 is a anti-SULT1C2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: SULT1C2
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, FACS, ELISA
Biological background
SULT1C2 is expressed mainly in fetal liver, kidney, and gastrointestinal tissues, with lower levels in adult organs. It plays an important role in the developmental regulation of xenobiotic metabolism. In the liver, SULT1C2 helps conjugate thyroid hormones, estrogens, and xenobiotic phenols, contributing to endocrine balance and protection from toxic compounds. Variations in SULT1C2 expression or activity influence drug metabolism, hormone clearance, and chemical susceptibility, making it relevant to pharmacogenetics and toxicology studies.
The SULT1C2 antibody is used to study enzymatic detoxification, hormone metabolism, and tissue-specific sulfation patterns. Western blot analysis identifies a 34 kilodalton band corresponding to SULT1C2, and immunohistochemistry reveals cytoplasmic localization in hepatocytes and renal tubular cells. This antibody supports research into the biochemical pathways of sulfate conjugation and developmental regulation of phase II metabolism. Because sulfotransferases influence drug bioavailability and toxicity, the SULT1C2 antibody is a valuable reagent for pharmacological and toxicological investigations.
Beyond metabolism, SULT1C2 may participate in cell signaling and differentiation by modulating the availability of bioactive molecules. Altered expression has been observed in cancers of the colon, liver, and lung, suggesting roles in tumor metabolism and chemical carcinogen processing.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
