| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human Synaptogyrin 1 recombinant protein (Position: S42-Y233) was used as the immunogen for the SYNGR1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SYNGR1 Antibody / Synaptogyrin 1 is a anti-SYNGR1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: SYNGR1
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, ICC, IF, FACS, ELISA
Biological background
Synaptogyrin 1 is abundantly expressed in neurons throughout the central and peripheral nervous systems, particularly within the hippocampus, cortex, and cerebellum. It colocalizes with synaptophysin at presynaptic terminals and has been implicated in modulating short-term synaptic plasticity. Genetic studies suggest that SYNGR1 plays a role in neuropsychiatric conditions including schizophrenia and bipolar disorder, where altered expression affects synaptic connectivity. By maintaining the balance between vesicle docking and endocytosis, Synaptogyrin 1 ensures efficient neurotransmission under repetitive stimulation.
The SYNGR1 antibody is widely used in neuroscience research to identify synaptic vesicles and study presynaptic organization. Immunohistochemical staining with this antibody shows punctate labeling along axons and synaptic terminals, corresponding to vesicle-rich regions. In western blot analysis, Synaptogyrin 1 appears as a 25 kilodalton band. Its high conservation allows cross-reactivity among mammalian species, making the antibody suitable for studies in human, mouse, and rat tissues. By labeling presynaptic vesicles, the SYNGR1 antibody facilitates mapping of synaptic networks and quantitative analysis of synapse density across brain regions.
Beyond basic neuroscience, Synaptogyrin 1 has clinical relevance. Expression profiling in neurodegenerative diseases such as Alzheimer's and Parkinson's reveals synaptic protein loss correlating with disease progression. Reduced SYNGR1 expression has also been linked to cognitive decline and altered synaptic activity in psychiatric disorders. Functionally, Synaptogyrin 1 may influence neurotransmitter transporter trafficking, including those for serotonin and dopamine. The antibody thus supports a broad range of studies spanning molecular synaptic physiology, disease biomarker discovery, and neural circuit mapping.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunofluorescence: visualize subcellular distribution and cell-to-cell heterogeneity.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
