| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human SYPL1 was used as the immunogen for the SYPL1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SYPL1 Antibody / Synaptophysin like protein 1 is a anti-SYPL1 Rabbit antibody Recombinant Rabbit Monoclonal clone 32S17 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human.
Key elements and design rationale
- Target: SYPL1
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 32S17, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB, IHC
Biological background
SYPL1 antibody is widely applied in research on vesicle biology, secretion, and cancer. SYPL1 has been implicated in regulated exocytosis, immune granule release, and membrane trafficking. In pancreatic islets, SYPL1 supports hormone release, while in immune cells it contributes to vesicular storage and secretion of signaling molecules. Detecting SYPL1 allows researchers to explore how vesicle associated proteins coordinate secretory pathways in different tissues.
The antibody is validated for western blotting, immunohistochemistry, and immunofluorescence. In western blot assays, SYPL1 antibody detects protein bands of the expected size, enabling assessment of expression across samples. Immunohistochemistry reveals SYPL1 expression in pancreas, spleen, and epithelial tissues. Immunofluorescence demonstrates punctate localization in vesicular structures consistent with roles in trafficking and secretion.
SYPL1 has also been studied in cancer biology. Elevated expression has been reported in hepatocellular carcinoma and other malignancies, where it correlates with proliferation, survival, and therapy resistance. By applying SYPL1 antibody, scientists can investigate how vesicle associated proteins contribute to oncogenesis and evaluate their potential as biomarkers or therapeutic targets.
SYPL1 also plays roles in development and immune regulation. In hematopoietic cells, it contributes to granule release and immune defense. In development, SYPL1 influences vesicle formation and trafficking, ensuring proper signaling during differentiation. This versatility highlights the importance of SYPL1 antibody in both basic biology and translational research.
SYPL1 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
