| Field | Specification |
|---|---|
| Target | |
| Alternative names | E3 ubiquitin-protein ligase synoviolin|RING-type E3 ubiquitin transferase synoviolin|Synovial apoptosis inhibitor 1|SYVN1|HRD1|KIAA1810 |
| Gene ID | |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | synovial apoptosis inhibitor 1, synoviolin |
| Conjugate | |
| Molecular weight | |
| Purity | |
| Purification | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Scientific Background
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control(ERQC) system also called ER-associated degradation(ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin(HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
Product Overview
This polyclonal antibody, raised in Rabbit, recognizes SYVN1. It is validated for ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation.
Validated Applications
| Applications | ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation |
|---|---|
| WB | 1:500-1:2000 |
| IP | 1:200-1:1000 |
| IHC | 1:20-1:200 |
Optimal dilutions should be determined by the end user for each application and sample type.
Immunogen
synovial apoptosis inhibitor 1, synoviolin
Specifications
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Immunogen | synovial apoptosis inhibitor 1, synoviolin |
| Purification | Immunogen Affinity Purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Form | Liquid |
| Target MW | 68-76 kDa |
| UniProt # | Q86TM6 |
| Gene ID | 84447 |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Alternative Names | E3 ubiquitin-protein ligase synoviolin|RING-type E3 ubiquitin transferase synoviolin|Synovial apoptosis inhibitor 1|SYVN1|HRD1|KIAA1810 |
Reactivity Notes
Validated reactivity: Human, Mouse, Rat. For other species, epitope conservation may allow cross-reactivity; confirm with appropriate controls.
Safety & Handling
This product is for research use only (RUO) and is not intended for diagnostic or therapeutic use. The formulation contains sodium azide; handle with standard laboratory precautions.
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Explore related antibodies and reagents for SYVN1 research from Fine Test, or contact us for alternative formats.
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