| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human TAOK2 recombinant protein (Position: H502-H1142) was used as the immunogen for the TAOK2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
TAOK2 Antibody / TAO kinase 2 is a anti-TAOK2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.
Key elements and design rationale
- Target: TAOK2
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, IHC, IF, FACS, ELISA
Biological background
TAOK2 plays a critical role in neuronal morphology and synaptic function. It regulates microtubule stability and axon elongation through phosphorylation of cytoskeletal proteins, including microtubule-associated proteins. In developing neurons, TAOK2 helps establish dendritic spine structure and connectivity, contributing to proper neural circuit formation. Mutations and deletions of TAOK2 have been linked to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia, underscoring its importance in brain development. Studies show that TAOK2 interacts with autism risk proteins including SHANK1 and DISC1 and modulates signaling through Rho GTPases and JNK kinases.
The TAOK2 gene is located on chromosome 16p11.2, a genomic region frequently associated with copy number variations implicated in neurodevelopmental conditions. TAOK2 exists in several alternatively spliced isoforms with distinct subcellular localization and regulatory functions. The full-length protein contains an N-terminal kinase domain and a C-terminal coiled-coil domain that mediates protein-protein interactions. TAOK2 activation can be induced by oxidative stress, UV radiation, or cytokine stimulation, linking it to broader cellular stress responses and apoptosis regulation.
Immunohistochemical staining using TAOK2 antibody shows expression in brain tissue, particularly in the cortex and hippocampus, as well as in heart and testis. It has been used to study MAPK pathway signaling, neuronal cytoskeleton remodeling, and stress-induced apoptosis. TAOK2 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunofluorescence: visualize subcellular distribution and cell-to-cell heterogeneity.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
