| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one |
| Cas No. | |
| Form | Off white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (25 mg/ml, warm) or water (weakly) |
| Source | Synthetic |
| Storage |
Temozolomide is an oral alkylating agent widely used in the treatment of glioblastoma multiforme and other brain tumors. It crosses the blood-brain barrier and induces DNA damage by methylating guanine residues, leading to apoptosis in rapidly dividing cells. In neuroscience, Temozolomide is also used to suppress neurogenesis in experimental models, allowing researchers to study the role of adult-born neurons in cognition and behavior. Its dual role as a chemotherapeutic agent and a neurogenesis modulator makes it a valuable tool in both oncology and neurobiology research.
Classification: Toxic
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
- H302 Harmful if swallowed.
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H335 May cause respiratory irritation.
- H350 May cause cancer.
- H360 May damage fertility or the unborn child.
Precautionary Phrases:
- P201 Obtain special instructions before use.
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P308 + P313 IF exposed or concerned: Get medical advice or attention.
Temozolomide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-363)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Gunther W., et al. (2003) Br. J. Cancer. 88: 463.
3. Danson S.J., et al. (2001) Expert Rev. Anticancer Ther. 10: 13.
4. Natsumeda M., et al. (2011) Neuropathology. 31: 486.
