| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human Teneurin 1/TENM1 recombinant protein (Position: M1-G502) was used as the immunogen for the TENM1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
TENM1 Antibody / Teneurin 1 is a anti-TENM1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Immunohistochemistry (IHC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human.
Key elements and design rationale
- Target: TENM1
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): IHC, IF, FACS, ELISA
Biological background
Teneurin 1 functions through both its extracellular and intracellular domains. The intracellular region can be proteolytically cleaved and translocated to the nucleus, where it may regulate gene transcription. The extracellular domain mediates adhesion between neurons and their target cells, guiding axons toward correct synaptic partners. Loss of TENM1 disrupts neural circuit formation and has been associated with neurodevelopmental disorders, including intellectual disability and autism spectrum conditions. The TENM1 antibody is a critical tool for investigating axon guidance mechanisms, neuronal differentiation, and cell adhesion processes within the central nervous system.
In addition to its developmental roles, Teneurin 1 contributes to cancer cell adhesion and metastasis. Aberrant expression has been detected in glioblastoma and neuroblastoma, linking TENM1 to oncogenic signaling pathways. The antibody detects both full-length membrane-bound and cleaved intracellular forms, supporting comprehensive study of its signaling functions. Immunohistochemical analysis reveals TENM1 localization along neuronal membranes and synaptic sites, while western blot identifies multiple high molecular weight bands reflecting post-translationally modified isoforms. The TENM1 antibody therefore serves as a versatile reagent for studies in neurobiology and tumor progression.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Immunofluorescence: visualize subcellular distribution and cell-to-cell heterogeneity.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
