| Field | Specification |
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| Activity | |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
TLR7/8 agonist 4 hydroxy-PEG10-acid (CAS 2388520-17-8) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2388520-17-8 |
|---|---|
| Molecular Formula | C41H68N6O12 |
| Molecular Weight | 837.02 g/mol |
| SMILES | CCCCc1nc2c(N)nc3ccc(cc3c2(nH)1)N1CCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
TLR7/8 agonist 4 hydroxy-PEG10-acid (compound 9) is a drug-linker conjugate employed in antibody-drug conjugates (ADC). This compound exhibits remarkable antitumor activity by utilizing TLR7/8 agonist 4, which acts as a potent activator of TLR7/8. The TLR7/8 agonist 4 is linked to hydroxy-PEG10-acid, the ADC linker, via a cleavable bond. Overall, it demonstrates promising pharmaceutical potential in the context of ADC-based therapeutics.
Target(s): Drug-Linker Conjugates for ADC, Others
Signaling pathway(s): Others, Antibody-drug Conjugate/ADC Related
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
When solubility is listed as < 1 mg/mL, the compound dissolves to less than 1 mg per milliliter in water at 25 °C, pH 7.4. Such compounds require an organic co-solvent such as DMSO to prepare a concentrated stock, which is then diluted into aqueous assay buffer. For cell-based assays, keep the final DMSO concentration below 0.1% (v/v) to avoid solvent-induced cytotoxicity.
After the stock solution is prepared, it is typically stored at -80°C and can be kept for over 1 year. It is recommended to aliquot to avoid repeated freeze-thaw cycles. For frequent use, it can be stored at 4°C for over a week.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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