| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human TMEM201 recombinant protein (Position: R38-R591) was used as the immunogen for the TMEM201 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
TMEM201 Antibody / Transmembrane protein 201 is a anti-TMEM201 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.
Key elements and design rationale
- Target: TMEM201
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, FACS, ELISA
Biological background
Biochemically, Transmembrane protein 201 contains luminal and cytoplasmic regions that permit associations with lamins and cytoskeletal adaptors. These interactions help maintain nuclear envelope integrity and may tune mechanotransduction, allowing cells to translate mechanical forces into gene-regulatory outcomes. Perturbation of Transmembrane protein 201 can disrupt centrosome orientation and impair cell polarity, emphasizing its role at the interface of structure and signaling. In endothelial systems, increased Transmembrane protein 201 activity has been linked with enhanced migration during angiogenic sprouting, underscoring its relevance to vascular biology.
Researchers use TMEM201 Antibody to define inner nuclear membrane architecture by immunofluorescence, co-localize the protein with lamins or SUN/KASH components, and quantify expression under conditions that alter cytoskeletal tension. In immunoblotting, the antibody detects endogenous Transmembrane protein 201 and can monitor isoform abundance or post-translational changes across cell states. Immunoprecipitation with TMEM201 Antibody enables mapping of protein partners at the nuclear envelope, supporting studies that connect nuclear mechanics to transcriptional control and cell fate decisions. Because nuclear positioning and mechanosensitive signaling influence differentiation, immunity, and cancer invasion, this reagent supports a wide set of experimental questions.
The TMEM201 Antibody from
As interest grows in how nuclear architecture governs cell behavior, TMEM201 Antibody provides a practical bridge between nuclear envelope structure and systems-level outcomes. Its use in standard immunocytochemistry, tissue immunohistochemistry, and pulldown experiments makes it a versatile tool for dissecting nuclear positioning, mechanotransduction, and angiogenesis, while helping connect biophysical cues to gene regulation and phenotype in both normal physiology and disease contexts.
TMEM201 Antibody supports rigorous inquiries into nuclear mechanics with a single, reliable probe that integrates cleanly into multicolor imaging, gel-based quantification, and interactome discovery workflows.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
