| Field | Specification |
|---|---|
| Mfr No | |
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| Host | |
| Immunogen | A synthesized peptide derived from human TNS4 was used as the immunogen for the TNS4 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
TNS4 Antibody / Tensin 4 / Cten is a anti-TNS4 Rabbit antibody Recombinant Rabbit Monoclonal clone 30T19 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: TNS4
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 30T19, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
TNS4 antibody is widely applied in cancer biology, cell adhesion studies, and migration research. TNS4 expression is elevated in colorectal, gastric, breast, and lung cancers, where it promotes epithelial mesenchymal transition, invasion, and metastasis. By detecting TNS4, researchers can evaluate how altered focal adhesion dynamics contribute to tumor progression. Its restricted expression in normal tissues and strong induction in tumors make it a promising biomarker for oncogenesis.
Applications of TNS4 antibody include western blotting, immunohistochemistry, and immunofluorescence. Western blot assays detect TNS4 protein in tumor cell lysates, immunohistochemistry maps expression in cancer biopsies, and immunofluorescence highlights localization at adhesion sites. These methods provide robust experimental approaches for studying cancer associated focal adhesion remodeling.
TNS4 interacts with integrins, focal adhesion kinase, and actin filaments, coordinating adhesion and signaling. Unlike other tensins, its lack of phosphatase activity suggests specialized roles in signaling rather than enzymatic regulation. By applying TNS4 antibody, scientists can dissect how this atypical tensin supports oncogenic processes. TNS4 expression correlates with poor prognosis, therapy resistance, and metastatic potential in multiple cancers.
Beyond cancer, TNS4 has roles in wound healing and tissue repair, where transient expression supports migration and remodeling. Its evolutionary divergence from other tensins highlights specialized functions. Detection with antibody based assays enables researchers to map these unique contributions across physiology and pathology.
TNS4 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
