| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | PHA 291639 phosphate |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Toceranib Phosphate (CAS 874819-74-6) is a research-grade small molecule supplied by TargetMol.
Alternative names: PHA 291639 phosphate
Physical Properties
| CAS Number | 874819-74-6 |
|---|---|
| Molecular Formula | C22H28FN4O6P |
| Molecular Weight | 494.45 g/mol |
| SMILES | OP(O)(O)=O.Cc1(nH)c(C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NCCN1CCCC1 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR
Target(s): PDGFR, c-Kit, Tyrosinase, VEGFR
Signaling pathway(s): Angiogenesis, Proteases/Proteasome, Tyrosine Kinase/Adaptors
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Most small molecule inhibitors are not compatible with autoclaving (121 °C), which can cause thermal decomposition or loss of biological activity. For sterile cell-based experiments, filter-sterilize working solutions through a 0.2 µm membrane after dilution into aqueous buffer. Verify thermal stability in the DataSheet before applying any heat treatment.
It is not recommended to store DMSO stock solutions at room temperature. Once the stock solution is prepared, aliquot into single-use volumes and store at −20 °C (or −80 °C for sensitive compounds). Room-temperature storage accelerates chemical degradation and moisture uptake. When ready to use, thaw an aliquot at room temperature, use immediately, and avoid repeated freeze-thaw cycles.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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