| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone, Tolcapone, Tasmar, Ro 40-7592 |
| Cas No. | |
| Form | Yellow powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (25 mg/ml), or ethanol (25 mg/ml) |
| Source | Synthetic |
| Storage |
Tolcapone is a potent catechol-O-methyltransferase (COMT) inhibitor that enhances dopaminergic signaling by preventing dopamine degradation. It is clinically used in Parkinson’s disease and has demonstrated neuroprotective effects by inhibiting alpha-synuclein and beta-amyloid aggregation. Tolcapone also binds transthyretin (TTR), stabilizing it and preventing TTR-induced cytotoxicity. These multifaceted actions make Tolcapone a valuable compound in neurodegenerative disease research, particularly in Parkinson’s and Alzheimer’s disease models.
Classification: Not WHMIS controlled
Hazard statement(s):
- H303 - May be harmful if swallowed.
- H400 - Very toxic to aquatic life.
- Precautionary statement(s)
- P273 Avoid release to the environment.
Tolcapone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-540)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. S Di Giovanni et al. J. Biol. Chem. 2010 285:14941
3. R Sant’Anna et al. Nat. Commun. 2016 7:10787
4. SC Forester and JD Lambert J. Funct. Foods 2015 17:183
