| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human TOR4A was used as the immunogen for the TOR4A antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
TOR4A Antibody / Torsin family 4 member A is a anti-TOR4A Rabbit antibody Recombinant Rabbit Monoclonal clone 29T65 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.
Key elements and design rationale
- Target: TOR4A
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 29T65, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
Torsin family 4 member A is part of a family of ATPases that contribute to protein folding, trafficking, and quality control. Research using TOR4A antibody has shown that the protein supports structural organization of the endoplasmic reticulum and nuclear envelope. By interacting with other torsin proteins, TOR4A participates in maintaining organelle integrity and proteostasis under basal and stress conditions.
Studies with TOR4A antibody have revealed that the protein is involved in nuclear envelope structure and potentially nuclear pore dynamics. Disruption of torsin family proteins has been linked to nuclear envelope abnormalities and impaired nucleocytoplasmic transport. These findings suggest that TOR4A contributes to essential processes that support gene regulation and cell signaling.
Dysregulation of TOR4A has been implicated in disease. Research using TOR4A antibody has shown associations with cancer progression and viral infection. Overexpression in certain cancers correlates with altered protein folding capacity and stress adaptation, while some pathogens exploit torsin family proteins for replication. These findings underscore the relevance of TOR4A in health and pathology.
TOR4A antibody is commonly applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects endogenous protein levels, immunohistochemistry reveals tissue-specific expression, and immunofluorescence demonstrates localization to the endoplasmic reticulum and nuclear envelope. These applications make TOR4A antibody valuable for cell biology research.
By providing validated TOR4A antibody reagents,
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
