| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | CHR-2797 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Tosedostat (CAS 238750-77-1) is a research-grade small molecule supplied by TargetMol.
Alternative names: CHR-2797
Physical Properties
| CAS Number | 238750-77-1 |
|---|---|
| Molecular Formula | C21H30N2O6 |
| Molecular Weight | 406.47 g/mol |
| SMILES | (CH)(NC((CH)((CH)(C(NO)=O)O)CC(C)C)=O)(C(OC1CCCC1)=O)C2=CC=CC=C2 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted intracellularly into a poorly membrane-permeable active metabolite (CHR-79888) which inhibits the M1 family of aminopeptidases, particularly puromycin-sensitive aminopeptidase (PuSA), and leukotriene A4 (LTA4) hydrolase; inhibition of these aminopeptidases in tumor cells may result in amino acid deprivation, inhibition of protein synthesis due to a decrease in the intracellular free amino acid pool, an increase in the level of the proapoptotic protein Noxa, and cell death.
Target(s): AChR, Aminopeptidase
Signaling pathway(s): Metabolism, Neuroscience
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
The concentration of stock solution should be lower than the solubility provided on the official website. Within this range, the concentration of stock solution should be set based on that of working solution. For cell experiments, it is recommended to set the stock solution concentration at least 1000 times higher than that of working solution.
For normal mice, the concentration of DMSO should be kept below 10%. For nude mice, transgenic mice, or mice with weak tolerance, the concentration of DMSO should be kept below 2%. For inhibitors being used for the first time, it is recommended to perform a solvent-negative control experiment to confirm that the solvent has no nonspecific effects on the animals.
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