| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | LJN452 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Tropifexor (CAS 1383816-29-2) is a research-grade small molecule supplied by TargetMol.
Alternative names: LJN452
Physical Properties
| CAS Number | 1383816-29-2 |
|---|---|
| Molecular Formula | C29H25F4N3O5S |
| Molecular Weight | 603.58 g/mol |
| SMILES | O(CC=1C(=NOC1C2CC2)C3=C(OC(F)(F)F)C=CC=C3)(CH)4C(C)5(N((C)(C4)(CC5)(H)… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
Target(s): Autophagy, FXR
Signaling pathway(s): Autophagy, Metabolism
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
After the stock solution is prepared, it is typically stored at -80°C and can be kept for over 1 year. It is recommended to aliquot to avoid repeated freeze-thaw cycles. For frequent use, it can be stored at 4°C for over a week.
For normal mice, the concentration of DMSO should be kept below 10%. For nude mice, transgenic mice, or mice with weak tolerance, the concentration of DMSO should be kept below 2%. For inhibitors being used for the first time, it is recommended to perform a solvent-negative control experiment to confirm that the solvent has no nonspecific effects on the animals.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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