| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | AMACR;Alpha-methylacyl-CoA racemase;2-methylacyl-CoA racemase |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthetic Peptide of AMACR |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® AMACR Mouse Monoclonal Antibody (4A12) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against AMACR. It has been validated for Western Blot, Immunofluorescence, Immunohistochemistry and reacts with Human, Mouse, Rat.
Validated Applications
| Target | AMACR |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 4A12 |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Western Blot, Immunofluorescence, Immunohistochemistry |
| Purification | Affinity Purified |
| Specificity | The antibody detects endogenous AMCAR/P504S proteins. |
| Molecular Weight | Observed: 42 kDa |
| UniProt / Swiss-Prot | Q9UHK6 (Human) | O09174 (Mouse) | P70473 (Rat) |
Recommended dilutions: WB 1:1000;IHC 1:200;IF 1:200
Immunogen / Antigen
Synthetic Peptide of AMACR
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
Safety & Handling
This antibody is validated for Western Blot, Immunofluorescence, Immunohistochemistry. Recommended dilutions: WB 1:1000;IHC 1:200;IF 1:200
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone 4A12.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
