| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | AI528660;AI662476;CD 105;CD105;CD105 antigen;EGLN_HUMAN;END;Endoglin;Eng;FLJ41744;HHT1;ORW;ORW1;Osler Rendu Weber syndrome 1;RP11 228B15.2;S endoglin;S-endoglin;SN6 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthesized peptide derived from human CD105(Endoglin) AA range: 400-500 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® CD105 (ABT-CD105) Mouse Monoclonal Antibody (WM1297) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against CD105(Endoglin). It has been validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA and reacts with Human.
Validated Applications
| Target | CD105(Endoglin) |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ABT-CD105 |
| Isotype | IgG2a, Kappa |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Immunohistochemistry, Western Blot, Immunofluorescence, ELISA |
| Purification | Protein G |
| Specificity | The antibody can specifically recognize human CD105 protein. |
| Molecular Weight | Calculated: 70 kDa | Observed: 75 kDa |
| UniProt / Swiss-Prot | P17813 (Human) |
Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Immunogen / Antigen
Synthesized peptide derived from human CD105(Endoglin) AA range: 400-500
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
CD105 is a homodimeric cell membrane glycoprotein linked by disulfide bonds. It is a new class of cell adhesion molecules and plays an important role in regulating angiogenesis. As a receptor of TGF-beta, CD105 is highly expressed in vascular endothelial cells of tumor related neovascular endothelium. Therefore, the evaluation of tumor microvessel density by immunohistochemical staining is significantly correlated with tumor invasion and prognosis.
Safety & Handling
This antibody is validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA. Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone ABT-CD105.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
