| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | CEPTR L2;CEPTRL 2;CEPTRL2;Claudin 1;Claudin 7;Claudin 9;Claudin-7;Claudin1;Claudin7;Claudin9;CLD7_HUMAN;CLDN 7;CLDN-7;CLDN7;Clostridium perfringens enterotoxin receptor like 2;CPETR L2;CPETRL 2;CPETRL2;Hs.84359 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthesized peptide derived from human Claudin 7 AA range: 100-211 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® Claudin 7 (ABT441) Mouse Monoclonal Antibody (WM1410) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against Claudin 7. It has been validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA and reacts with Human, Mouse, Rat.
Validated Applications
| Target | Claudin 7 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ABT441 |
| Isotype | IgG2b, Kappa |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Immunohistochemistry, Western Blot, Immunofluorescence, ELISA |
| Purification | Protein G |
| Specificity | The antibody can specifically recognize human Claudin 7 protein. In western blotting of LnCap cell lysate, the antibody can label a 22 kDa band corresponding to Claudin 7. |
| Molecular Weight | Calculated: 22 kDa | Observed: 22 kDa |
| UniProt / Swiss-Prot | O95471 (Human) | Q9Z261 (Mouse) | Q9Z1L1 (Rat) |
Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Immunogen / Antigen
Synthesized peptide derived from human Claudin 7 AA range: 100-211
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
Claudin 7 is a 22 kDa membrane protein, belonging to the tight junction protein family. Claudin family proteins play an important role in cell polarity, signal transduction and the pathogenesis of a variety of malignant tumors. It has been reported that compared with non neoplastic mucosal tissues, the expression of claudin 7 in laryngeal squamous cell carcinoma is down-regulated, and the expression level is related to distant metastasis, which can be used as a potential predictor of poor prognosis. Therefore, claudin 7 may be a useful immunohistochemical marker for the diagnosis, metastasis and prognosis of laryngeal cancer.
Safety & Handling
This antibody is validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA. Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone ABT441.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
