| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | CEPTR L2;CEPTRL 2;CEPTRL2;Claudin 1;Claudin 7;Claudin 9;Claudin-7;Claudin1;Claudin7;Claudin9;CLD7_HUMAN;CLDN 7;CLDN-7;CLDN7;Clostridium perfringens enterotoxin receptor like 2;CPETR L2;CPETRL 2;CPETRL2;Hs.84359 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthesized peptide derived from human Claudin 7 AA range: 100-211 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® Claudin 7 (ABT443) Mouse Monoclonal Antibody (WM1247) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against Claudin 7. It has been validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA and reacts with Human.
Validated Applications
| Target | Claudin 7 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ABT443 |
| Isotype | IgG2b, Kappa |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Immunohistochemistry, Western Blot, Immunofluorescence, ELISA |
| Purification | Protein G |
| Specificity | The antibody can specifically recognize human Claudin 7 protein. In western blotting of LnCap cell lysate, the antibody can label a 22 kDa band corresponding to Claudin 7. |
| Molecular Weight | Calculated: 22 kDa | Observed: 22 kDa |
| UniProt / Swiss-Prot | O95471 (Human) | Q9Z261 (Mouse) | Q9Z1L1 (Rat) |
Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Immunogen / Antigen
Synthesized peptide derived from human Claudin 7 AA range: 100-211
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
Safety & Handling
This antibody is validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA. Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone ABT443.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
