| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | PARP1;ADPRT;PPOL;Poly [ADP-ribose] polymerase 1;PARP-1;ADP-ribosyltransferase diphtheria toxin-like 1;ARTD1;NAD;+;ADP-ribosyltransferase 1;ADPRT 1;Poly[ADP-ribose] synthase 1 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthetic Peptide of Cleaved PARP |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® Cleaved PARP Mouse Monoclonal Antibody (Mix) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against PARP. It has been validated for Immunofluorescence, Western Blot, Immunohistochemistry and reacts with Human.
Validated Applications
| Target | PARP |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Immunofluorescence, Western Blot, Immunohistochemistry |
| Purification | Affinity Purified |
| Specificity | The antibody detects endogenous pro and active PARP protein. |
| Molecular Weight | Observed: 116,89 kDa |
| UniProt / Swiss-Prot | P09874 (Human) | P11103 (Mouse) | P27008 (Rat) |
Recommended dilutions: IF 1:50-200;WB 1:2000-5000;IHC 1:50-300
Immunogen / Antigen
Synthetic Peptide of Cleaved PARP
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Safety & Handling
This antibody is validated for Immunofluorescence, Western Blot, Immunohistochemistry. Recommended dilutions: IF 1:50-200;WB 1:2000-5000;IHC 1:50-300
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
