| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | URMC099 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
URMC-099 (CAS 1229582-33-5) is a research-grade small molecule supplied by TargetMol.
Alternative names: URMC099
Physical Properties
| CAS Number | 1229582-33-5 |
|---|---|
| Molecular Formula | C27H27N5 |
| Molecular Weight | 421.54 g/mol |
| SMILES | C(C1=CC=C(C=2C=C3C(=CNC3=NC2)C=4C=C5C(=CC4)NC=C5)C=C1)N6CCN(C)CC6 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
Target(s): Bcr-Abl, Src, MEK, Syk, Autophagy, IGF-1R, LRRK2, c-Met/HGFR, SGK, VEGFR, ROCK, MLK, Aurora Kinase, Trk receptor, DNA Alkylation, CDK
Signaling pathway(s): MAPK, Angiogenesis, Autophagy, DNA Damage/DNA Repair, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Stem Cells, Metabolism, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
It is not recommended to store DMSO stock solutions at room temperature. Once the stock solution is prepared, aliquot into single-use volumes and store at −20 °C (or −80 °C for sensitive compounds). Room-temperature storage accelerates chemical degradation and moisture uptake. When ready to use, thaw an aliquot at room temperature, use immediately, and avoid repeated freeze-thaw cycles.
Yes — TargetMol inhibitors can be used in cell-based and in vitro experiments. Prepare a DMSO stock, then dilute into cell culture medium to the desired working concentration, keeping DMSO ≤ 0.1% (v/v) to avoid solvent toxicity. Note that not all compounds have published data for every cell line or assay system; in such cases, perform a dose-response experiment with appropriate positive and vehicle controls to validate efficacy in your specific model.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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