| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; or 2',7-Dihydroxy-3,4-benzocoumarin |
| Cas No. | |
| Form | Pale-yellow powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (50 mg/ml) |
| Source | Synthetic |
| Storage |
Urolithin A is a gut microbiota-derived metabolite of dietary ellagitannins, known for its ability to induce mitophagy and improve mitochondrial health. In neurodegenerative disease research, Urolithin A has demonstrated neuroprotective effects by promoting mitophagy and suppressing NLRP3 inflammasome activation in microglial cells. These mechanisms are particularly relevant in models of Parkinson’s disease and Alzheimer’s disease, where mitochondrial dysfunction and neuroinflammation are key pathological features. Urolithin A also enhances T cell function ex vivo, suggesting broader implications for immune modulation in neurodegenerative conditions.
Classification: Irritant GHS07
Hazard Statements
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
Precautionary Statement Codes
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364
Urolithin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-610)
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2.Ryu D., et al. 2016 Nat. Med. 22:879
3.Qiu J., et al. 2022 Neuropharmacology 207:108963
4.Jayatunga D.P.W., et al. 2021 Nutrients. 13:3744
5.Denk D., et al. 2022 Immunity. 55:2059
