| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Muconomycin-A; 379-Y; Glutinosin-I; Myrothecin-I; NSC-126728 |
| Cas No. | |
| Form | Off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (25 mg/ml) |
| Source | Synthetic |
| Storage |
Verrucarin A is a macrocyclic trichothecene mycotoxin with potent cytotoxic and anti-cancer properties. In neurodegenerative disease research, it has been investigated for its ability to modulate amyloid-beta production in Alzheimer’s disease models. It selectively downregulates steroid receptor coactivator-3 and inhibits endoplasmic reticulum stress, suggesting potential for targeting protein misfolding and cellular stress pathways in neurodegeneration.
Classification: Danger. Hazard Statements
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]
H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]
Precautionary Statement Codes:
P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
Verrucarin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-614)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. F Yan et al. PLOS One 2014 9(4):e95243
3. K Palanivel et al. Tumour Biol. 2014 35:10159
4. RG Jayasooriya et al. Environ. Toxicol. Pharmacol. 2013 36:303
5. D-O Moon et al. Toxicol. In Vitro 2013 27:257 6. EY Bae et al. Molecules 2015 20:8989
