| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Suberoylanilide-hydroxamic acid; Vorinostat; N-Hydroxy-N'-phenyloctanediamide |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol |
| Source | Synthetic |
| Storage |
SAHA (Vorinostat) is a potent, cell-permeable HDAC inhibitor with significant implications in neurodegenerative disease research and neuro-oncology. By altering chromatin structure and gene expression, SAHA promotes neuronal differentiation, reduces neuroinflammation, and enhances synaptic function.
Its ability to synergize with kinase inhibitors to target CNS tumors also positions it as a promising agent in glioblastoma therapy. Widely cited in oncology for its pro-apoptotic effects, SAHA is increasingly recognized in neuroscience for its role in epigenetic modulation and neuroprotection, making it a valuable compound in translational research.
Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Hazard Statements:
H341-H360 (Suspected of causing genetic defects)
Precautionary Statements:
P201-P281-P308 + P313
Vorinostat (SAHA) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-359)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Butler L.M., et al., (2002) Proc. Natl. Acad. Sci. USA. 99: 11700.
3. Tang Y., et al., (2012) Cancer Biol. Ther. 2012 13(7): 567-574.
