| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human WDR37 recombinant protein (Position: D161-Q451) was used as the immunogen for the WDR37 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
WDR37 Antibody / WD repeat-containing protein 37 is a anti-WDR37 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: WDR37
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, FACS, ELISA
Biological background
WDR37 is encoded by the WDR37 gene located on human chromosome 10p15.1. The protein is ubiquitously expressed, with higher levels in brain, kidney, and reproductive tissues. Its precise molecular function remains under investigation, but emerging evidence suggests roles in intracellular signaling and vesicle trafficking. Mutations in WDR37 have been linked to a congenital neurodevelopmental disorder featuring craniofacial and ocular anomalies, underscoring its importance in human development. Studies in animal models indicate that Wdr37 contributes to ciliary and cytoskeletal organization, reflecting a potential connection to ciliopathies.
Using the WDR37 antibody, researchers can detect the native ~55 kDa protein via western blot and localize it through immunofluorescence microscopy. Expression analysis demonstrates cytoplasmic and perinuclear localization, consistent with a role in vesicular trafficking. The antibody is also useful in co-immunoprecipitation experiments for identifying interacting partners within signaling and transport complexes. Functional studies are beginning to connect WDR37 with cell cycle progression and protein degradation pathways, suggesting a role in maintaining proteostasis.
WD repeat proteins like WDR37 often act as adaptors within ubiquitin ligase complexes, G-protein signaling pathways, or RNA splicing assemblies. Understanding WDR37 biology could shed light on how these complexes maintain cellular organization and developmental homeostasis.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
