| Field | Specification |
|---|---|
| Activity | |
| Alternative Names | XX 650 23 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
XX-650-23 (CAS 117739-40-9) is a research-grade small molecule supplied by TargetMol.
Alternative names: XX 650 23
Physical Properties
| CAS Number | 117739-40-9 |
|---|---|
| Molecular Formula | C18H12N2O2 |
| Molecular Weight | 288.30 g/mol |
| SMILES | NCC1=CC=C(C=C1)NC(=O)C2=CC=3C=CC=CC3C=C2O |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
XX-650-23 is a small molecule CREB inhibitor that blocks the critical interaction between CREB and its required coactivator, CBP (CREB-binding protein), inducing apoptosis and cell cycle arrest in AML cells, and can be used in the study of acute myelogenous leukaemia (AML).
Target(s): Epigenetic Reader Domain, Apoptosis
Signaling pathway(s): Chromatin/Epigenetic, Apoptosis
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
When solubility is listed as < 1 mg/mL, the compound dissolves to less than 1 mg per milliliter in water at 25 °C, pH 7.4. Such compounds require an organic co-solvent such as DMSO to prepare a concentrated stock, which is then diluted into aqueous assay buffer. For cell-based assays, keep the final DMSO concentration below 0.1% (v/v) to avoid solvent-induced cytotoxicity.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
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