| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E. coli-derived zebrafish Myca recombinant protein (amino acids K21-H419) was used as the immunogen for the Zebrafish Myca antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
Zebrafish Myca Antibody / Myc-A / c-Myc-A is a anti-Zebrafish Myca Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.
Key elements and design rationale
- Target: Zebrafish Myca
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig
- Format: Antigen affinity purified
- Applications (as listed): WB
Biological background
Myc A functions by forming heterodimers with other transcriptional regulators and binding to specific DNA sequences to activate or repress target genes. It promotes the expression of genes involved in cell cycle progression, protein synthesis, and energy metabolism, while also modulating genes associated with apoptosis and cellular stress responses. This makes Myc A critical for balancing growth signals with environmental and developmental cues.
During zebrafish development, Myc A is expressed in proliferative regions such as the brain, somites, and hematopoietic tissues. Its expression is tightly regulated to ensure proper tissue formation and to prevent excessive or disorganized cell growth. Dysregulation of Myc A can lead to developmental abnormalities and has been linked to tumor formation in zebrafish models, making it a valuable tool in cancer biology research.
Because of its strong conservation across vertebrates and its fundamental role in transcriptional control, zebrafish Myc A is widely used in studies of developmental genetics, stem cell function, oncogenesis, and metabolic regulation.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
