| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | KZR-616 maleate |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Zetomipzomib maleate (CAS 2170983-62-5) is a research-grade small molecule supplied by TargetMol.
Alternative names: KZR-616 maleate
Physical Properties
| CAS Number | 2170983-62-5 |
|---|---|
| Molecular Formula | C34H46N4O12 |
| Molecular Weight | 702.76 g/mol |
| SMILES | OC(=O)C=C/C(O)=O.COc1ccc(cc1)(CH)(O)(CH)(NC(=O)(CH)(C)NC(=O)CN1CCOCC1)… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Zetomipzomib maleate (KZR-616), a novel immunoproteasome inhibitor, effectively and selectively inhibits the LMP7 subunit (hLMP7/mLMP7 IC50: 39/57 nM) and LMP2 subunit (hLMP7/mLMP7 IC50: 131/179 nM) of the immunoproteasome. This compound shows promising potential for research in various autoimmune diseases.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
Yes — TargetMol inhibitors can be used in cell-based and in vitro experiments. Prepare a DMSO stock, then dilute into cell culture medium to the desired working concentration, keeping DMSO ≤ 0.1% (v/v) to avoid solvent toxicity. Note that not all compounds have published data for every cell line or assay system; in such cases, perform a dose-response experiment with appropriate positive and vehicle controls to validate efficacy in your specific model.
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