ZINC58368839

Product details

• Chemical name: N-cycloheptyl-N-methyl-2-(5-nitroindol-1-yl)acetamide.
• Also known as: N-cycloheptyl-N-methyl-2-(5-nitro-1H-indol-1-yl)acetamide, T6869826, Z905437510
• PubChem CID: 51127177
• Molecular formula: C18H23N3O3.
• Purity: >97%
• Concentration: 5-50 µM.
• Form: Lyophilized Powder
• Solubility: Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
• Reconstitution: Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: P2X7 channels
• Source: Synthetic
• Activity: ZINC58368839 is a novel antagonist of purinergic P2X7 receptors, shown to inhibit BzATP-induced Ca2+ responses in HEK-hP2X7 cells with IC50 of 4.8 µM1.
• Alternative names: N-cycloheptyl-N-methyl-2-(5-nitro-1H-indol-1-yl)acetamide, T6869826, Z905437510

Scientific background

ZINC58368839 inhibits P2X7 receptors by binding to the ATP-binding pocket of the receptor and demonstrates strong specificity towards human P2X7R over human P2X4R and rat P2X3R1. It inhibits BzATP-induced Ca2+ responses in HEK-hP2X7 cells with IC50 value of 4.8 µM1.P2X receptors are cationic trimeric channel complexes that function as ATP-gated Ca2+-permeable channels. They are considered to be an attractive therapeutic target. This family includes seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are ubiquitously expressed, and particularly in cells of haematopoietic origin1,2.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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