6BIO

6BIO is a potent, reversible, and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β), as well as an inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Its ability to modulate the Wnt signaling pathway has made it a valuable tool in stem cell biology, particularly for maintaining self-renewal and pluripotency in embryonic stem cells. Although its primary applications have been in developmental biology and cancer research, emerging evidence suggests that GSK-3 inhibition may have neuroprotective effects. In the context of neurodegenerative diseases, 6BIO’s modulation of GSK-3 activity could influence tau phosphorylation and amyloid precursor protein processing, both of which are implicated in Alzheimer’s disease. This positions 6BIO as a compound of growing interest in neuroscience, particularly for its potential to modulate key signaling pathways involved in neuronal survival and plasticity.

Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity-single exposure ( Category 3 ), Respiratory system, H335

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H315 Causes skin irritation.
• H319 Causes serious eye irritation.
• H335 May cause respiratory irritation.

Precautionary statements:

• P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
• P264 Wash skin thoroughly after handling.
• P271 Use only outdoors or in a well-ventilated area.
• P280 Wear protective gloves/ eye protection/ face protection.
• P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
• P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
• P305 + P351 + P338

IF IN EYES:

• Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
• P321 Specific treatment (see supplemental first aid instru
• ctions on this label).
• P332 + P313 If skin irritation occurs: Get medical advice/ attention.
• P337 + P313 If eye irritation persists: Get medical advice/ attention.
• P362 Take off contaminated clothing and wash before reuse.
• P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
• P405 Store locked up.
• P501 Dispose of contents/ container to an approved waste disposal plant.

6BIO (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-422)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).