| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human AAMP was used as the immunogen for the AAMP antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
AAMP Antibody / Angio associated migratory cell protein is a anti-AAMP Rabbit antibody Recombinant Rabbit Monoclonal clone 29A85 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: AAMP
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 29A85, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB, ICC, IF, FACS
Biological background
AAMP antibody is widely applied in vascular biology and cancer research. Studies have shown that AAMP promotes endothelial cell migration and tube formation, making it a critical factor in angiogenesis. By detecting AAMP expression, researchers can study mechanisms of vascular remodeling in normal physiology and disease. Altered levels of AAMP have been linked to pathological angiogenesis observed in tumor growth and metastasis, highlighting its potential as a therapeutic target.
The antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, AAMP antibody detects specific protein bands, enabling quantitative comparisons across samples. In immunohistochemistry, it provides visualization of AAMP distribution in tissues, with high expression observed in vascular structures. Immunofluorescence studies highlight its subcellular localization and interactions with cytoskeletal elements. These applications make AAMP antibody a versatile reagent for cell and molecular biology.
In addition to its role in angiogenesis, AAMP contributes to immune regulation. It has been implicated in modulating lymphocyte adhesion and migration. By using AAMP antibody, researchers can investigate how AAMP facilitates immune cell trafficking and its contribution to inflammation and immune surveillance.
Cancer biology has further underscored the importance of AAMP. Upregulation has been linked to enhanced tumor cell motility and invasiveness. Its interactions with heparin binding proteins and integrins influence the tumor microenvironment and promote vascular support for malignant growth. Detecting AAMP with specific antibodies provides insight into how cancer cells exploit normal migratory mechanisms to drive progression.
AAMP antibody provided by
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunofluorescence: visualize subcellular distribution and cell-to-cell heterogeneity.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
