| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-Amino-N,N'-bis(6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide |
| Cas No. | |
| Form | Red-orange powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 50 mM in DMSO |
| Source | Synthetic |
| Storage |
Actinomycin D is a polypeptide antibiotic that inhibits transcription by binding to DNA and preventing RNA polymerase elongation. In neuroscience, it is used to study gene expression regulation, transcriptional responses to stress, and the role of RNA synthesis in neuronal survival and plasticity.
Classification: Very Toxic. May be fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
- R26/27/28 - Very Toxic by inhalation, in contact with skin and if swallowed
- R36/37/38 - Irritating to eyes, respiratory system and skin
- R40 - Limited evidence of a carcinogenic effect
- R62 - Possible risk of impaired fertility
Hazard Phrases:
H300 – Fatal if swallowed
Precautionary Phrases:
P264 –P301 + P310
Actinomycin D (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-245)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Turan T., et al. (2006) Int J Gynecol Cancer. 16(3): 1432-1438.
