AG 494

AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase. It specifically blocks EGFR autophosphorylation and EGF-dependent cell proliferation. In neuroscience, AG 494 is used to investigate the role of EGFR signaling in neural development, gliogenesis, and neuroinflammation. Its ability to modulate growth factor signaling makes it a valuable tool for studying glioblastoma and other EGFR-related neuropathologies.

Classification: Not a hazardous substance or mixture.

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

AG 494 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-491)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).