| Field | Specification |
|---|---|
| Alternative names | 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C25H29I2NO3•HCl |
| Purity | |
| Bioactivity | Inducer |
| Activity | |
| Solubility | Soluble to 50 mM in DMSO |
| SMILES | |
| InChIKey | |
| Form | White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Amiodarone Hydrochloride is a non-selective ion channel blocker primarily used as an antiarrhythmic agent. In neuroscience, Amiodarone has been shown to induce autophagy by inhibiting mTORC1, a key regulator of cellular metabolism and protein turnover. In yeast models, it triggers calcium influx, mitochondrial fragmentation, and cell death—mechanisms that parallel neurodegenerative processes. Amiodarone’s ability to modulate autophagy and mitochondrial dynamics makes it a useful compound for studying neurodegeneration, particularly in models of Parkinson’s disease and other disorders involving mitochondrial dysfunction. Its broad-spectrum activity also supports research into ion channel regulation and calcium signaling in neuronal cells.
Classification: D1B- Toxic Material Causing Immediate and Serious, Toxic Effects, Toxic by inhalation.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H303- May be harmful if swallowed.
- H312 + H332- Harmful in contact with skin or if inhaled
Precautionary statements:
P280- Wear protective gloves/ protective clothing.
Amiodarone Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-393)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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2. Balgi A., et al. (2009). PLoS One. 4(9): e7124.
