| Field | Specification |
|---|---|
| Target | |
| Alternative names | Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human Activin Receptor Type IIB |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 22A31 is a rabbit monoclonal antibody that recognizes activin receptor type-2B (gene ACVR2B) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 57.7 kDa, and the supplier reports an observed band at about 65 kDa.
Activin receptor type-2B (ACVR2B) is a type II serine/threonine kinase receptor for activins, myostatin, GDF11 and other TGF-β family members. It activates type I receptors and SMAD signaling and is studied in muscle mass control, left-right patterning and development.
| Target | Activin receptor type-2B (gene ACVR2B; UniProt Q13705, human) |
|---|---|
| Clone | 22A31 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 57.7 kDa |
| Observed MW | 65 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Samples with a confirmed band (WB): K562 cells, mouse heart.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide based on the sequence of human activin Receptor Type IIB.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places activin receptor type-2B in the cell membrane. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
