| Field | Specification |
|---|---|
| Target | |
| Alternative names | B2 bradykinin receptor;B2R;BK-2 receptor;BDKRB2;BKR2; |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human BDKRB2, different from the related mouse sequence by five amino acids, and from the related rat sequence by seven amino acids. |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody targets B2 bradykinin receptor (gene BDKRB2) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 44.5 kDa, and the supplier reports an observed band at about 78 kDa.
The B2 bradykinin receptor (BDKRB2) is a constitutively expressed G protein-coupled receptor for bradykinin and kallidin. It signals through Gq, phospholipase C and Ca2+ and mediates vasodilation, vascular permeability, pain and inflammation. BDKRB2 is the target of icatibant, which is used to treat hereditary angioedema attacks.
| Target | B2 bradykinin receptor (gene BDKRB2; UniProt P30411, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Calculated MW | 44.5 kDa |
| Observed MW | 78 kDa |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.1–0.5 µg/mL (Human, Mouse, Rat) |
|---|
Samples with a confirmed band (WB): human Hacat cells, human A431 cells, human A549 cells, human MCF-7 cells, rat C6 cells, mouse Neuro-2a cells.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide from the C-terminal region of human BDKRB2. It differs from the mouse sequence at five residues and from the rat sequence at seven residues.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places B2 bradykinin receptor in the cell membrane. Tissue expression noted by UniProt (human): Ubiquitous. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
