Anti-BZW2 Antibody Picoband®

Overview

Anti-BZW2 Antibody Picoband® is an antibody for BZW2 detection raised in Rabbit (Polyclonal, Rabbit IgG), with reported reactivity: Human,Mouse,Rat. Commonly used in WB, IHC, Flow Cytometry, ELISA workflows.

Key elements and design rationale

• Target: BZW2 (eva-1 homolog A, regulator of programmed cell death); UniProt: Q9Y6E2
• Antibody format: Rabbit, Polyclonal, Rabbit IgG
• Molecular weight: 48 kDa
• Applications: WB, IHC, Flow Cytometry, ELISA

Vendor description (summary): Boster Bio Anti-BZW2 Antibody Picoband® catalog # A11832-1.

Biological background

Biological context: Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

Expression and localization notes: cellular localization: Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane., tissue context: Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle..

Common research applications

• Western blotting (WB): Compare BZW2 levels across samples and conditions using appropriate loading and biological controls.
• Immunohistochemistry (IHC): Evaluate spatial distribution of BZW2 in tissue sections, considering fixation and antigen retrieval effects.
• Flow cytometry: Quantify BZW2-positive populations in single-cell suspensions with appropriate gating and controls.
• ELISA: Use antibody-based detection formats to assess antigen presence or binding in plate-based assays.

Notes for experimental interpretation

• Account for isoforms, post-translational modifications, and sample-specific processing that can shift apparent molecular weight or epitope accessibility.
• Use positive/negative biological controls where possible (e.g., known-expressing cells/tissues, knockdown/knockout models) and include appropriate secondary-only/isotype controls for imaging workflows.

Additional product notes (from provided fields)

• Background: Basic Leucine Zipper and W2 Domain-Containing Protein 2 is a protein that is encoded by the BZW2 gene. BZW2, also known as HSPC028 or MSTP017, is a 419 amino acid protein that contains one W2 domain and is thought to be involved in neuronal differentiation. The gene encoding BZW2 maps to human chromosome 7. Chromosome 7 houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders, including cases of acute myelogenous leukemia and myelodysplasia.
• Cross reactivity: No cross-reactivity with other proteins.
• Cellular localization: Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.
• Tissue details: Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.
• Research category: Cell Biology,Proteasome / Ubiquitin,Proteolysis/Ubiquitin,Ubiquitin E3 Enzymes

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.