| Field | Specification |
|---|---|
| Target | |
| Alternative names | Junction plakoglobin;Jup; |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Recombinant chicken plakoglobin. |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 15F11 is a mouse monoclonal antibody that recognizes junction plakoglobin (gene Jup) in bovine and human samples and is validated for Western blot, IHC and ICC/IF.
Plakoglobin (JUP, also called γ-catenin) is an armadillo-repeat protein closely related to β-catenin. It is a structural component of desmosomes and adherens junctions, where it links cadherins to the cytoskeleton and helps cells resist mechanical stress, and it can substitute for β-catenin in cadherin–catenin complexes. Mutations in JUP are linked to arrhythmogenic cardiomyopathy and skin disorders such as Naxos disease.
| Target | Junction plakoglobin (gene Jup; UniProt Q6P0K8, rat) |
|---|---|
| Clone | 15F11 |
| Host / Clonality / Isotype | Mouse / Monoclonal / Mouse IgG1 |
| Reactivity | Bovine, Human |
| Purification | Ascites |
| Form | Lyophilized |
| Formulation | 1.2% sodium acetate; 0.01 mg NaN3; plus stabilizers |
| Reconstitution | 100 µg/mL after adding 1 mL PBS |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1 µg/mL (Human, Bovine) |
|---|---|
| Immunohistochemistry | Not specified by the supplier |
| Immunocytochemistry / Immunofluorescence | Not specified by the supplier |
Immunogen
Recombinant chicken plakoglobin.
Reactivity Notes
The supplier lists reactivity with bovine and human. UniProt places junction plakoglobin in the cell junction, cytoplasm, cell membrane and nucleus. Tissue expression noted by UniProt (rat): Expressed in the heart (at protein level).
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
