| Field | Specification |
|---|---|
| Target | |
| Alternative names | Cathepsin D;3.4.23.5;Cathepsin D 12 kDa light chain;Cathepsin D 9 kDa light chain;Cathepsin D 34 kDa heavy chain;Cathepsin D 30 kDa heavy chain;Ctsd; |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Human liver cathepsin D. |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Catalog no. (Mfr.) | |
| Main SKU |
Overview
Anti-Cathepsin D Ctsd Monoclonal Antibody is an antibody targeting CTSD. Common applications include WB, IHC. Key specifications include host: Mouse; clonality: Monoclonal; clone: Clone: CTD-19; isotype: Mouse IgG2a; reactivity: Human; observed MW: 28 kDa; calculated MW: 44681 MW.
Boster Bio Anti-Cathepsin D Ctsd Monoclonal Antibody catalog # MA1013. Tested in IHC, WB applications. This antibody reacts with Human.
Key elements and design rationale
- Target: CTSD — Cathepsin D
- Antibody format: Host: Mouse; Clonality: Monoclonal; Clone: Clone: CTD-19; Isotype: Mouse IgG2a
- Species reactivity: Human
- Molecular weight guidance: Observed: 28 kDa; Calculated: 44681 MW
Specificity note: No cross reactivity with other proteins.
Biological background
Protein function (datasheet): Acid protease active in intracellular protein breakdown.
Scientific background (datasheet): Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Cathepsin D is mapped to chromosome 11. The amino acid sequence predicted from the cDNA sequence shows that human cathepsin D consists of 412 amino acids with 20 and 44 amino acids in a pre- and a prosegment, respectively.
Cellular localization (datasheet): Lysosome. Melanosome . Secreted, extracellular space .
Tissue details (datasheet): CTSD: Expressed in the aorta extrcellular space (atprotein level).
Sequence similarities (datasheet): Belongs to the peptidase A1 family.
Research relevance and current trends
- Commonly studied in contexts related to Cancer,Cell Adhesion Proteins,Cell Biology,Cytoskeleton/ECM,ECM Enzymes,Extracellular Matrix,Invasion/Microenvironment,Membrane Proteins,Neuroscience,Proteolysis/Ubiquitin,Proteolytic Enzymes,Signal Transduction.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Cross-reactivity (datasheet): No cross-reactivity with other proteins
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
